Be anxious for nothing, but in everything by prayer and supplication with thanksgiving let your requests be made known to God.  And the peace of God, which surpasses all comprehension, will guard your hearts and your minds in Christ Jesus.

Background
God created in humans, His children, a tendency to look forward into the future for the hope of something better.  God, even better than a loving and wise parent, has plans for a good future for us.  While the primary target of that is an eternity in Heaven where sin will no longer reign and people there will have wholesome relationships, we can get a taste of it here.  If we are seeking first the two greatest commandments, we will find peace and purpose even in places that are undesirable because of the sins of this world.

What it meant to the original audience
The letter to the Philippians was written by Paul while he was in prison and they, like many of the new churches established at that time, were experiencing a variety of pressures from the surrounding society and the Jews.  But Paul was enthusiastic because of the spiritual growth he was seeing in them and the other churches.  And they were excited because of all that the Gospel had brought to their lives.

For us today
Today, the more we seek the two greatest commandments, the more we will experience both joy and persecution.  But, if we understand who God is and what He is doing, the more that anxieties will be replaced with peace and purpose.

Ultimate peace and purpose come only from a close relationship with God.